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tipiracil

Indications: - used in combination with trifluridine in the treatment of metastatic colorectal adenocarcinoma Mechanism of action: - inhibits thymidine phosphorylase

General

enzyme inhibitor antineoplastic agent (chemotherapeutic agent)

Database Correlations

PUBCHEM correlations

References

  1. Mayer RJ et al. Randomized trial of TAS-102 for refractory metastatic colorectal cancer. N Engl J Med 2015 May 14; 372:1909 PMID: 25970050 http://www.nejm.org/doi/full/10.1056/NEJMoa1414325

Component-of

tipiracil/trifluridine; TAS-102 (Lonsurf)