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TIM22 complex
Function:
- mediates import & insertion of multipass transmembrane proteins into the mitochondrial inner membrane (see TIMM22)
Structure:
- subunits: composed of TIMM22, associated with peripheral protein FXC1/TIM10B & the 70 kD heterohexamer
Related
70 kD heterohexamer
General
molecular complex
Properties
SUBUNITS: mitochondrial import inner membrane translocase subunit TIM22
COMPARTMENT: mitochondria
cellular membrane
MOTIF: exoplasmic domain {N-TERMINAL}
transmembrane domain {74-94}
transmembrane domain {123-143}
cytoplasmic domain {C-TERMINAL}
transmembrane domain {170-190}
mitochondrial import inner membrane translocase subunit TIM9B
COMPARTMENT: mitochondria
MOTIF: Twin CX3C {28-52}
MOTIF: cysteine residue {C28}
MODIFICATION: cysteine residue {C52}
cysteine residue {C32}
MODIFICATION: cysteine residue {C48}
cysteine residue {C48}
MODIFICATION: cysteine residue {C32}
cysteine residue {C52}
MODIFICATION: cysteine residue {C28}
70 kD heterohexamer
References
UniProt :accession Q99595
Components
70 kD heterohexamer
mitochondrial import inner membrane translocase subunit TIM22 (testis-expressed sequence 4, TIMM22, TEX4, TIM22)
mitochondrial import inner membrane translocase subunit TIM9B (fracture callus protein 1, FxC1, TIM10B)