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tyrosine-protein kinase receptor Tie-1 (TIE1, TIE)
Function:
- probable protein tyrosine-kinase transmembrane receptor
Structure:
- belongs to the protein kinase superfamily, Tyr protein kinase family, Tie subfamily
- contains 3 EGF-like domains
- contains 3 fibronectin F3 modules
- contains 2 Ig-like C2-type domains (immunoglobulin-like)
- contains 1 protein kinase domain
Compartment: membrane
Expression:
- specifically expressed in developing vascular endothelial cells
General
glycoprotein
tyrosine kinase receptor (RTK)
Properties
SIZE: entity length = 1138 aa
MW = 125 kD
COMPARTMENT: cellular membrane
STATE: active state
MOTIF: signal sequence {1-21}
immunoglobulin superfamily domain {43-105}
MOTIF: N-glycosylation site {N83}
N-glycosylation site {N161}
EGF domain {214-256}
MOTIF: cysteine residue {C228}
MODIFICATION: cysteine residue {C237}
cysteine residue {C231}
MODIFICATION: cysteine residue {C244}
cysteine residue {C237}
MODIFICATION: cysteine residue {C228}
cysteine residue {C244}
MODIFICATION: cysteine residue {C231}
cysteine residue {C246}
MODIFICATION: cysteine residue {C255}
cysteine residue {C255}
MODIFICATION: cysteine residue {C246}
EGF domain {258-303}
EGF domain {305-345}
MOTIF: cysteine residue {C315}
MODIFICATION: cysteine residue {C327}
cysteine residue {C321}
MODIFICATION: cysteine residue {C333}
cysteine residue {C327}
MODIFICATION: cysteine residue {C315}
cysteine residue {C333}
MODIFICATION: cysteine residue {C321}
cysteine residue {C335}
MODIFICATION: cysteine residue {C344}
cysteine residue {C344}
MODIFICATION: cysteine residue {C335}
immunoglobulin superfamily domain {372-426}
fibronectin type III domain or F3 module {446-537}
MOTIF: N-glycosylation site {N503}
fibronectin type III domain or F3 module {545-637}
MOTIF: N-glycosylation site {N596}
fibronectin type III domain or F3 module {644-736}
MOTIF: N-glycosylation site {N709}
transmembrane domain {760-784}
kinase domain
SITE: 839-1118
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 845-853
ATP-binding site
NAME: ATP-binding site
SITE: 870-870
aspartate residue {D979}
Tyr phosphorylation site {Y1007}
Database Correlations
OMIM 600222
UniProt P35590
PFAM correlations
Kegg hsa:7075
ENZYME 2.7.10.1
References
UniProt :accession P35590