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tianeptine
approved in Europe, not in U.S.
Adverse effects:
- tachycardia
- agitation
- nausea
- withdrawal consistent with opioid withdrawal
Drug interactions:
- use in association with benzodiazepines associated with worse outcomes
Complications:
- U.S. poison control centers identified 218 calls for tianeptine exposure from 2000-2017, 80 calls in both 2016 & 2017
- reports of
- seizures, loss of consciousness, cardiac arrest, death [2]
Interactions
drug adverse effects of tricyclic antidepressants
General
tricyclic antidepressant (TCA)
opioid receptor agonist (narcotic)
References
- El Zahran T, Schier J, Glidden E, et al.
Characteristics of Tianeptine Exposures Reported to the National
Poison Data System - United States, 2000-2017.
MMWR Morb Mortal Wkly Rep 2018;67:815-818
https://www.cdc.gov/mmwr/volumes/67/wr/mm6730a2.htm
- Robertson R
What Is Tianeptine and Why Is It in Demand?
Here's why this unregulated compound is known as "gas station heroin".
MedPage Today February 1, 2024
https://www.medpagetoday.com/special-reports/features/108541