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thyrotropin-releasing hormone-degrading ectoenzyme; TRH-DE; TRH-degrading ectoenzyme; EC=3.4.19.6; pyroglutamyl-peptidase II; PAP-II; TRH-specific aminopeptidase; thyroliberinase (TRHDE)
Function:
- specific inactivation of TRH after its release
- release of the N-terminal pyroglutamyl group from pGlu-|-His-Xaa tripeptides & pGlu-|-His-Xaa-Gly tetrapeptides
Cofactor: binds 1 Zn+2 per subunit (putative)
Structure:
- homodimer; disulfide-linked (putative)
- belongs to the peptidase M1 family
Compartment:
- membrane; single-pass type 2 membrane protein
Expression: predominantly expressed in brain
General
aminopeptidase
glycoprotein
membrane protein
Properties
SIZE: entity length = 1024 aa
MW = 117 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {41-61}
cysteine residue {C68}
MODIFICATION: cysteine residue {C-INTERCHAIN}
N-glycosylation site {N89}
N-glycosylation site {N160}
N-glycosylation site {N175}
N-glycosylation site {N222}
N-glycosylation site {N338}
Substrate binding {404-408}
Zn+2-binding site
SITE: 440-440
glutamate residue {E441}
Zn+2-binding site
SITE: 444-444
Zn+2-binding site
SITE: 463-463
tyrosine residue {527}
N-glycosylation site {N605}
N-glycosylation site {N634}
N-glycosylation site {N649}
N-glycosylation site {N663}
N-glycosylation site {N684}
N-glycosylation site {N800}
N-glycosylation site {N906}
Database Correlations
OMIM 606950
UniProt Q9UKU6
Pfam PF01433
Entrez Gene 29953
Kegg hsa:29953
ENZYME 3.4.19.6
References
UniProt :accession Q9UKU6