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thyroid transcription factor 1; NK-2 (drosophila) homolog A; thyroid nuclear factor (TTF1, NKX2A, NKX2-1)
Function:
- may play role in surfactant homeostasis
Expression:
- thyroid
- pulmonary epithelial cells
Embryogenesis:
- thyroid
- diencephalon
- respiratory epithelium
Pathology:
- expressed in:
a) thyroid tumors (all histologic types)
b) lung carcinomas
1] adenocarcinomas ~75%
2] non-small cell carcinomas ~63%
3] neuroendocrine/small cell carcinomas >90%
4] squamous carcinomas ~10%
Related
cytokeratin-7+TTF1 Ag in tissue
thyroid transcription factor 1 Ag in tissue
General
DNA-binding protein
homeobox protein
Properties
SIZE: MW = 38 kD
entity length = 371 aa
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
Database Correlations
OMIM 600635
MORBIDMAP 600635
UniProt P43699
References
- Dabbs. Diagnostic Immunohistochemistry. Churchill Livingstone 2002.
page 181, 269.
- UniProt :accession P43699