59 kD 2'-5'-oligoadenylate synthase-like protein; thyroid receptor-interacting protein 14; TR-interacting protein 14; TRIP-14; p59 OASL; p59OASL (OASL, TRIP14)

Function: - does not have 2'-5'-oligoadenylate synthase activity, but binds double-stranded RNA & DNA - specifically interacts with the ligand binding domain of the thyroid receptor - TRIP14 does not require the presence of thyroid hormone for its interaction - binds MBD1 Structure: - belongs to the 2-5A synthase family - contains 2 ubiquitin-like domains Alternative splicing: named isoforms=2 Expression: - expressed in most tissues - highest expression in peripheral blood Leukocytes & other hematopoietic tissues, colon, stomach - lesser expression in testis - induced by interferons Comparative biology: - this may not be the true ortholog of mouse OASL

General

DNA-binding protein thyroid hormone receptor interacting protein (TRIP)

Properties

SIZE: entity length = 514 aa MW = 59 kD COMPARTMENT: cell nucleus MOTIF: Ubiquitin-like 1 {354-433} Ubiquitin-like 2 {434-509}

Database Correlations

OMIM 603281 UniProt Q15646 PFAM correlations Entrez Gene 8638 Kegg hsa:8638

References

UniProt :accession Q15646