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thyroid receptor-interacting protein 1; 26S proteasome regulatory subunit 8 (TRIP1, ATPase-5, PSMC5, SUG1)
Function:
- component of 26S protease
- interacts, in vitro, with the thyroid hormone receptor (T3-dependent) & with retinoid X receptor (RXR) (putative)
- interacts with NDC80
- interacts with PAAF1
Structure:
- belongs to the AAA ATPase family
- homologous to the yeast transcriptional mediator Sug1
Compartment: cytoplasm (putative), nucleus (putative)
Expression:
- ubiquitously expressed
General
thyroid hormone receptor interacting protein (TRIP)
transcription factor (TF)
Properties
SIZE: entity length = 406 aa
MW = 46 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
ATP-binding site
NAME: ATP-binding site
SITE: 190-197
binding site
FOR-BINDING-OF: triiodothyronine [T3] receptor
retinoid X receptor (RXR)
Database Correlations
OMIM 601681
UniProt P62195
Pfam PF00004
Kegg hsa:5705
References
- Lee JW, Ryan F, Swaffield JC, Johnston SA, Moore DD.
Interaction of thyroid-hormone receptor with a conserved
transcriptional mediator.
Nature. 1995 Mar 2;374(6517):91-4.
PMID: 7870181
- UniProt :accession P62195
Component-of
26S proteasome