thyroid hormone receptor-associated protein 2 (thyroid hormone receptor-associated protein complex 240 kD component-like, THRAP2, KIAA1025, PROSIT240, TRAP240L)

Function: - component of the mediator complex - transcriptional coactivation - phosphorylated upon DNA damage, probably by ATM or ATR Structure: - belongs to the mediator complex subunit 13 family Compartment: nucleus (probable) Expression: - highly expressed in brain (cerebellum, fetal brain), heart (aorta), skeletal muscle, kidney, placenta, peripheral blood leukocytes Pathology: - defects in THRAP2 are associated with transposition of the great arteries - dextro-looped - translocation t(12;17)(q24.1;q21) identified in one patient with transposition of the great arteries, dextro-looped & mental retardation

General

phosphoprotein transcriptional adaptor protein; transcriptional coactivator

Properties

SIZE: MW = 243 kD entity length = 2210 aa COMPARTMENT: cell nucleus MOTIF: leucine zipper SITE: 1380-1401 FOR-BINDING-VIA: leucine zipper serine-rich region {1566-1610} MOTIF: serine residue (SEVERAL)

Database Correlations

OMIM correlations MORBIDMAP 608771 UniProt Q71F56 PFAM correlations Entrez Gene 23389 Kegg hsa:23389

References

UniProt :accession Q71F56