thymosin beta-4; T beta-4; Fx; contains: hematopoietic system regulatory peptide; seraspenide (TMSB4X, TB4X, THYB4, TMSB4)

Function: - role in the organization of the cytoskeleton (putative) - binds to & sequesters actin monomers (G actin) & thus inhibits actin polymerization - seraspenide inhibits entry of hematopoietic pluripotent stem cells into the S-phase (putative) Structure: belongs to the thymosin beta family Compartment: cytoplasm, cytoskeleton Expression: - expressed in several hemopoietic cell lines & lymphoid malignant cells - decreased levels in myeloma cells - induced by alpha interferons - decreased levels in THP-1 cells after treatment with recombinant interferon-lambda

Properties

SIZE: entity length = 44 aa MW = 5 kD COMPARTMENT: cytoplasm MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Thr phosphorylation site {T23}

Database Correlations

OMIM 300159 UniProt P62328 Pfam PF01290 Entrez Gene 7114 Kegg hsa:7114

References

UniProt :accession P62328