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thymopoietin beta; lamina-associated polypeptide 2, isoform beta; thymopoietin, isoform beta; TP beta; thymopoietin-related peptide isoform beta; TPRP isoform beta; contains: thymopoietin; TP; splenin; TP5 (TMPO, LAP2)
Function:
- may help direct assembly of the nuclear lamina & thus help maintain the structural organization of the nuclear envelope
- possible receptor for attachment of lamin filaments to the inner nuclear membrane
- may be involved in the control of initiation of DNA replication through its interaction with NAKAP95
- TP & TP5 may play a role in T-cell development & function
- TP5 is an immunomodulating pentapeptide
- mitosis-specific phosphorylation specifically abolishes its binding to lamin B & chromosomes (putative)
- interacts with LMNB1, LMNB2, BANF1, AKAP8L, GMCL & chromosomes (putative)
Structure:
- as two structurally independent, non-interacting domains:
- LEM-like (also called LAP2-N or LEM-D)
- LEM-like binds DNA
- LEM (also called LAP2-C or LEM-B)
- LEM interacts with BANF1
- belongs to the LEM family
- contains 1 LEM domain
- contains 1 LEM-like domain
- contains sequence for putative hydrophobic membrane spanning domain from exon 8
Compartment:
- nuclear inner membrane
- single-pass type 2 membrane protein
- tightly associated with the nuclear lamina
Alternative splicing:
- named isoforms=3; alpha, beta, gamma
- additional isoforms seem to exist
Expression:
- expressed in many tissues
- most abundant in adult thymus & fetal liver
Pharmacology:
- TP5 is available under the names Timunox (Cilag), Sintomodulina (Italofarmaco) & Mepentil (Recordati)
- used in treatment of primary & secondary immune deficiencies, autoimmunity, infections & cancer
General
hormone
phosphoprotein
secreted protein
Properties
SIZE: entity length = 454 aa
MW = 51 kD
COMPARTMENT: cell nucleus
FORM: thymopoietin beta
MOTIF: Nucleoplasmic {2-410}
MOTIF: LEM-like {5-48}
Linker {49-108}
Thr phosphorylation site {T57}
Ser phosphorylation site {S66}
Ser phosphorylation site {S67}
Thr phosphorylation site {T74}
Ser phosphorylation site {S79}
Thr phosphorylation site {T96}
Thr phosphorylation site {T99}
LEM domain {109-153}
Thr phosphorylation site {T137}
binding site
SITE: 138-243
FOR-BINDING-OF: A-kinase anchor protein 8-like
Ser phosphorylation site {S156}
Ser phosphorylation site {S159}
Thr phosphorylation site {T160}
Thr phosphorylation site {T164}
Ser phosphorylation site {S177}
Ser phosphorylation site {S180}
Ser phosphorylation site {S184}
Thr phosphorylation site {T208}
Thr phosphorylation site {T211}
Ser phosphorylation site {S292}
Binds lamins B {299-371}
binding site
SITE: 300-374
FOR-BINDING-OF: A-kinase anchor protein 8-like
Ser phosphorylation site {S306}
Ser phosphorylation site {S315}
Ser phosphorylation site {S354}
Thr phosphorylation site {T355}
Ser phosphorylation site {S362}
Ser phosphorylation site {S378}
Ser phosphorylation site {S385}
transmembrane domain {411-434}
Database Correlations
OMIM 188380
MORBIDMAP 188380
UniProt P42167
PFAM correlations
Entrez Gene 7112
Kegg hsa:7112
References
UniProt :accession P42167