Search
thymidylate synthase; TS; TSase (TYMS, TS, OK/SW-cl29)
Function:
- pyrimidine metabolism; dTTP biosynthesis
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP
Structure:
- homodimer
- belongs to the thymidylate synthase family
Laboratory:
- TYMS genotyping
Interactions
molecular events
Related
folate metabolism
N5,N10-methylenetetrahydrofolate
General
methyltransferase
oxidoreductase
phosphoprotein
Properties
SIZE: entity length = 313 aa
MW = 36 kD
MOTIF: Ser phosphorylation site {S114}
cysteine residue {C195}
Database Correlations
OMIM 188350
UniProt P04818
Pfam PF00303
Entrez Gene 7298
Kegg hsa:7298
ENZYME 2.1.1.45
References
- UniProt :accession P04818
- SHMPD; The Singapore human mutation and polymorphism database
http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=TYMS