Search
thymidine phosphorylase; TP; gliostatin; platelet-derived endothelial cell growth factor; PD-ECGF; TdRPase (TYMP, ECGF1)
Function:
- may have a role in maintaining integrity of blood vessels
- growth promoting activity on endothelial cells, angiogenic activity in vivo & chemotactic activity on endothelial cells in vitro
- catalyzes reversible phosphorolysis of thymidine
- the produced molecules are utilized as carbon & energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
- pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2
thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate
Structure:
- homodimer
- belongs to the thymidine/pyrimidine-nucleoside phosphorylase family
Pathology:
- defects in TYMP are the cause of mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)
General
kinase or ATP-phosphotransferase
oligomerizing protein
Properties
SIZE: entity length = 482 aa
MW = 50 kD
MOTIF: kinase domain
MOTIF: ATP-binding site
NAME: ATP-binding site
consensus repeat {265-279}
SEQUENCE-IS: R-V-A-A-A-L-X(5,6)-L-G-R
consensus repeat {329-342}
SEQUENCE-IS: R-V-A-A-A-L-X(5,6)-L-G-R
consensus repeat {393-401}
SEQUENCE-IS: R-A-L-X-X-A-L-V-L
consensus repeat {453-461}
SEQUENCE-IS: R-A-L-X-X-A-L-V-L
Database Correlations
OMIM correlations
MORBIDMAP 131222
UniProt P19971
PFAM correlations
Entrez Gene 1890
Kegg hsa:1890
ENZYME 2.4.2.4
References
- UniProt :accession P19971
- R&D systems' cytokine mini-reviews: PD-ECGF
http://www.rndsystems.com/molecule_detail.aspx?m=1965
- GeneReviews
http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/TYMP