thymic stromal lymphopoietin (TSLP)

Function: - cytokine that induces release of T cell-attracting chemokines from monocytes &, in particular, enhances the maturation of CD11c+ dendritic cells - can induce allergic inflammation by directly activating mast cells - interacts with a receptor composed of CRLF2 & IL7R Compartment: secreted Expression: - expressed in a number of tissues including heart, liver & prostate - released by primary epithelial cells in response to certain microbial products, physical injury, or inflammatory cytokines

General

glycoprotein secreted protein

Properties

SIZE: entity length = 159 aa MW = 18 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-28} N-glycosylation site {N64} N-glycosylation site {N119}

Database Correlations

OMIM 607003 UniProt Q969D9

References

UniProt :accession Q969D9