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cytochrome p450 5A; thromboxane A [TxA] synthase 1 (TBXAS1, CYP5, CYP5A1)
Function:
- synthesis of thromboxane A
Cofactor: heme-thiolate
Structure:
- monomer
- belongs to the cytochrome P450 family
Compartment: endoplasmic reticulum membrane
Alternative splicing: named isoforms=4
Expression:
- platelets, lung, kidney, spleen, macrophages & lung fibroblasts
Pathology:
- defects in TBXAS1 are the cause of thromboxane synthetase deficiency
- defects in TBXAS1 are the cause of Ghosal hematodiaphyseal dysplasia
Note:
- uncertain whether Met-1 is the initiator
- an alternative upstream Met is found in primates
- not found in other mammals
Interactions
molecular events
Related
cyclooxygenase cascade
General
cytochrome P450
human longevity protein
isomerase
transmembrane 4 protein
Properties
SIZE: entity length = 533 aa
MW = 61 kD
COMPARTMENT: endoplasmic reticulum
MOTIF: cytoplasmic domain {1-10}
transmembrane domain {11-31}
exoplasmic loop {32-75}
transmembrane domain {76-96}
cytoplasmic loop {97-223}
transmembrane domain {224-244}
exoplasmic loop {245-335}
transmembrane domain {336-356}
cytoplasmic domain {357-533}
MOTIF: Iron [Fe]-binding site
SITE: 479-479
Database Correlations
OMIM correlations
UniProt P24557
Pfam PF00067
Entrez Gene 6916
Kegg hsa:6916
ENZYME 5.3.99.5
References
- Textbook of Biochemistry with Clinical Correlations,
3rd ed., TM Devlin (ed), Wiley-Liss, NY 1992 pg 465
- Cytochrome P450 Allele Nomenclature committee
CYP5A1 alleles
http://www.cypalleles.ki.se/cyp5a1.htm
- UniProt :accession P24557