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thrombospondin
Function:
- following release from platelet alpha granules, thrombospondin complexes with fibrinogen, fibronectin, plasminogen, & histidine-rich glycoprotein, & fibrin when it appears
- one of the characterized complexes is the trimolecular complex of thrombospondin:plasminogen:histidine-rich glycoprotein
- these complexes are formed intercellularly within the platelet aggregate & serve to change the weak intermolecular bridges formed by interaction of fibrinogen & glycoprotein IIb/IIIa into a stronger interplatelet link
Interactions
molecular events
Specific
thrombospondin-1 (THBS1, TSP, TSP1)
thrombospondin-2 (THBS2, TSP2)
thrombospondin-3 (THBS3, TSP3)
Thrombospondin-4 (THBS4 TSP4)
General
Ca+2 binding protein
glycoprotein
plasma protein
Properties
COMPARTMENT: plasma
MOTIF: EF hand (8)
glycosylation site
thrombospondin module (4)
EGF domain (3)
WKS motif
binding site
FOR-BINDING-OF: plasminogen
SECRETED-BY: platelet
References
- Baron M, Norman DG, Campbell ID.
Protein modules.
Trends Biochem Sci. 1991 Jan;16(1):13-7. Review.
PMID: 2053133
- Andrews BS.
Is the WKS motif the tissue-factor binding site for coagulation
factor VII?
Trends Biochem Sci. 1991 Jan;16(1):31-6. Review.
PMID: 2053135
- Fibrinolysis, Thrombosis, & Hemostasis: Concepts,
Perspectives, and Clinical Applications. S Sherry,
Lea & Febiger, Philadelphia, 1992, pg 86