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thrombopoietin receptor agonist
Indications:
- treatment of immune-mediated thrombocytopenia
Contraindications:
- chemotherapy-induced thrombocytopenia
Mechanism of action:
- stimulates platelet production via thrombopoietin receptor
Related
thrombopoietin receptor; TPO-R; myeloproliferative leukemia protein; C-mpl; CD110 (MPL, TPOR)
Specific
avatrombopag (Doptelet)
eltrombopag (AKR-501, Promacta)
lusutrombopag (Mulpleta)
romiplostim (AMG531, Nplate)
thrombopoietin; megakaryocyte colony stimulating factor; C-MPL ligand; megakaryocyte growth & development factor (MGDF, THPO)
General
hematologic agent
receptor agonist
References
- Medical Knowledge Self Assessment Program (MKSAP) 17,
American College of Physicians, Philadelphia 2015