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thrombopoietin; megakaryocyte colony stimulating factor; C-MPL ligand; megakaryocyte growth & development factor (MGDF, THPO)

Function: - cytokine that regulates megakaryocyte development - acts at a late stage of megakaryocyte development - may be the major physiological regulator of circulating platelets - ligand for Mpl receptor Structure: - two-domain structure with an erythropoietin-like N-terminal & a Ser/Pro/Thr-rich C-terminal - belongs to the EPO/TPO family - at least two forms, 25 kDa & 31 kDa Compartment: secreted Alternative splicing: named isoforms=3 Pathology: - defects in THPO are a cause of essential thrombocythemia Pharmacology: - avatrombopag (Doptelet) is a thrombopoietin receptor agonist that stimulates platelet production [5] Laboratory: - thrombopoietin in plasma Comparative biology: - cDNAs for human, dog & mouse predict proteins of 353, 352 & 356 amino acids respectively.

Related

megakaryocyte thrombopoietin receptor; TPO-R; myeloproliferative leukemia protein; C-mpl; CD110 (MPL, TPOR)

General

cytokine glycoprotein thrombopoietin receptor agonist

Properties

SIZE: entity length = 353 aa MW = 38 kD COMPARTMENT: extracellular compartment MOTIF: Ser glycosylation site {S22} signal sequence {1-21} cysteine residue {C28} MODIFICATION: cysteine residue {C172} cysteine residue {C50} MODIFICATION: cysteine residue {C106} Thr glycosylation site {T58} cysteine residue {C106} MODIFICATION: cysteine residue {C50} Thr glycosylation site {T131} cysteine residue {C172} MODIFICATION: cysteine residue {C28} Thr glycosylation site {T179} Thr glycosylation site {T180} Ser glycosylation site {S184} N-glycosylation site {N197} N-glycosylation site {N206} Thr glycosylation site {T213} N-glycosylation site {N234} N-glycosylation site {N255} Ser glycosylation site {S265} proline-rich region SITE: 285-337 MOTIF: proline residue (SEVERAL) N-glycosylation site {N340} N-glycosylation site {N348}

Database Correlations

OMIM correlations UniProt P40225 Pfam PF00758 Entrez Gene 7066 Kegg hsa:7066

References

  1. Bartley TD et al Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 77:1117-24 1994 PMID: 8020099
  2. UniProt :accession P40225
  3. R&D systems' cytokine source book: Thrombopoietin http://www.rndsystems.com/molecule_detail.aspx?m=2168
  4. GeneReviews http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/TPO
  5. Brooks M FDA OKs Platelet Booster for Liver Disease Patients . Medscape - May 21, 2018 https://www.medscape.com/viewarticle/897029