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thromboplastin; tissue factor; TF; coagulation factor III; CD142 (F3)
Function:
- membrane protein linked to either phosphatidyl ethanolamine or phosphatidylcholine
- binds factor VII or factor VIIa markedly increasing proteolytic activity of factor VIIa towards its primary substrate, factor X & factor IX
- initiates cell-surface assembly & propagation of the extrinsic coagulation cascade
Structure: belongs to the tissue factor family
Compartment: membrane
Expression:
- expression is highly dependent upon cell type
- induced by inflammatory mediators interleukin 1 & TNF, as well as by endotoxin
- appears on surface of monocytes & vascular endothelial cells as a component of cellular immune response
Interactions
molecular events
Related
thrombin/thromboplastin (Thrombinar)
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
cell surface receptor
glycoprotein
Properties
SIZE: entity length = 295 aa
MW = 33 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-32}
peptide motif {46-48}
peptide motif {77-79}
cysteine residue {C81}
MODIFICATION: cysteine residue {C89}
cysteine residue {C89}
MODIFICATION: cysteine residue {C81}
N-glycosylation site {N156}
N-glycosylation site {N169}
peptide motif {190-192}
cysteine residue {C218}
MODIFICATION: cysteine residue {C241}
cysteine residue {C241}
MODIFICATION: cysteine residue {C218}
transmembrane domain {252-274}
cysteine residue {C277}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM 134390
UniProt P13726
Pfam PF01108
Entrez Gene 2152
Kegg hsa:2152
References
- Clinical Diagnosis & Management by Laboratory
Methods, J.B. Henry (ed), W.B. Saunders Co.,
Philadelphia, PA. 1991, pg 735
- Andrews BS.
Is the WKS motif the tissue-factor binding site for coagulation
factor VII?
Trends Biochem Sci. 1991 Jan;16(1):31-6. Review.
PMID: 2053135
- Fibrinolysis, Thrombosis, & Hemostasis: Concepts,
Perspectives, & Clinical Applications. S Sherry,
Lea & Febiger, Philadelphia, 1992, pg 76
- UniProt :accession P13726
- SeattleSNPs
http://pga.gs.washington.edu/data/f3/
SHMPD; Singapore human mutation and polymorphism database
http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=TF
- Wikipedia; Note: Tissue factor entry
http://en.wikipedia.org/wiki/Tissue_factor
Component-of
thrombin/thromboplastin (Thrombinar)
macromolecular complex