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proteinase-activated receptor 3; PAR-3; thrombin receptor-like 2; coagulation factor II receptor-like 2 (F2RL2, PAR3)
Function:
- receptor for activated thrombin
- coupled to G proteins that stimulate phosphoinositide hydrolysis
- interacts with INSC/inscuteable & probably GPSM2
- proteolytic cleavage generates a new N-terminus that functions as a tethered ligand
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- highest expression in the megakaryocytes of the bone marrow
- lower expression in mature megakaryocytes, platelets, heart, GI tract
Related
thrombin receptor; proteinase-activated receptor 1; PAR-1; coagulation factor 2 receptor (F2R, CF2R, PAR1, TR)
thrombin; coagulation factor IIa
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 374 aa
MW = 43 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-94}
MOTIF: signal sequence {1-21}
N-glycosylation site {N25}
peptide motif {38-39}
N-glycosylation site {N82}
transmembrane domain {95-120}
cytoplasmic loop {121-128}
transmembrane domain {129-148}
exoplasmic loop {149-167}
MOTIF: cysteine residue {C166}
MODIFICATION: cysteine residue {C245}
transmembrane domain {168-189}
cytoplasmic loop {190-206}
transmembrane domain {207-230}
exoplasmic loop {231-260}
MOTIF: cysteine residue {C245}
MODIFICATION: cysteine residue {C166}
transmembrane domain {261-280}
cytoplasmic loop {281-297}
transmembrane domain {298-322}
exoplasmic loop {323-336}
MOTIF: N-glycosylation site {N331}
transmembrane domain {337-361}
cytoplasmic domain {362-374}
Database Correlations
OMIM 601919
UniProt O00254
Pfam PF00001
Kegg hsa:2151
References
- UniProt :accession O00254
- SeattleSNPs
http://pga.gs.washington.edu/data/f2rl2/