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thrombin receptor; proteinase-activated receptor 1; PAR-1; coagulation factor 2 receptor (F2R, CF2R, PAR1, TR)
Function:
- high affinity receptor for activated thrombin
- coupled to G proteins that stimulate phosphoinositide hydrolysis (Gi protein & Gp protein)
- may play a role in platelets activation & in vascular development
- thrombin specifically cleaves its receptor in an extracellular domain leading to self activation
- proteolytic cleavage generates a new N-terminus that functions as a tethered ligand
- phosphorylated; probably mediating desensitization prior to the uncoupling & internalization of the receptor
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane; multi-pass membrane protein
Expression: platelets & vascular endothelial cells
Interactions
molecular events
Related
proteinase-activated receptor 3; PAR-3; thrombin receptor-like 2; coagulation factor II receptor-like 2 (F2RL2, PAR3)
thrombin; coagulation factor IIa
Specific
thrombin receptor activating peptide-6
General
glycoprotein
phosphoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 425 aa
MW = 47 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-102}
MOTIF: signal sequence {1-26}
N-glycosylation site {N35}
peptide motif {41-42}
acidic region {57-60}
MOTIF: acidic residue (SEVERAL)
N-glycosylation site {N62}
N-glycosylation site {N75}
transmembrane domain {103-128}
cytoplasmic loop {129-137}
transmembrane domain {138-157}
exoplasmic loop {158-176}
MOTIF: cysteine residue {C175}
MODIFICATION: cysteine residue {C254}
transmembrane domain {177-198}
cytoplasmic loop {199-218}
transmembrane domain {219-239}
exoplasmic loop {240-268}
MOTIF: N-glycosylation site {N250}
cysteine residue {C254}
MODIFICATION: cysteine residue {C175}
N-glycosylation site {N259}
transmembrane domain {269-288}
cytoplasmic loop {289-311}
transmembrane domain {312-334}
exoplasmic loop {335-350}
transmembrane domain {351-374}
cytoplasmic domain {375-425}
Database Correlations
OMIM 187930
UniProt P25116
Pfam PF00001
Kegg hsa:2149
References
- Barnard EA.
Receptor classes and the transmitter-gated ion channels.
Trends Biochem Sci. 1992 Oct;17(10):368-74. Review.
PMID: 1360717
- Marcus AJ, Safier LB.
Thromboregulation: multicellular modulation of platelet
reactivity in hemostasis and thrombosis.
FASEB J. 1993 Apr 1;7(6):516-22. Review.
PMID: 8472890
- UniProt :accession P25116
- SeattleSNPs
http://pga.gs.washington.edu/data/f2r/
Component-of
molecular complex