THO/TREX complex

Function: - recruited to transcribed genes & travels with RNA polymerase during elongation - may physically link proteins that function in transcription & in RNA export Structure: subunits: THOC1, THOC2, THOC3, THOC4, NFX1

General

molecular complex nuclear protein

Properties

COMPARTMENT: cell nucleus SUBUNITS: exportin 1 COMPARTMENT: cytoplasm cell nucleus MOTIF: Necessary for HTLV-1 Rex-mediated mRNA export {1-679} MOTIF: Importin N-terminal {46-112} HEAT repeat {217-240} HEAT repeat {241-277} domain {327-450} HEAT repeat {354-472} Ser phosphorylation site {S391} Ser phosphorylation site {S397} RANBP3 interaction {411-481} domain {411-414} HEAT repeat {515-553} HEAT repeat {560-597} HEAT repeat {602-639} HEAT repeat {775-813} HIV-1 Rev interaction {800-820} HEAT repeat {885-916} HEAT repeat {917-954} HEAT repeat {1002-1039} MOTIF: Ser phosphorylation site {S1031}

References

UniProt :accession Q86V81