THO subcomplex

Function: - component of TREX complex - together with THOC3, THOC4 & DDX39B, THO forms the transcription/export complex (TREX complex) Structure: - subunits include: THOC1, THOC2, THOC5, THOC6 & THOC7

Properties

SUBUNITS: THO complex subunit 1 COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S560} death domain NAME: death domain SITE: 570-653 THO complex subunit 2 COMPARTMENT: cell nucleus MOTIF: nuclear translocation signal {808-813} Ser phosphorylation site {S1107} lysine-rich region {1149-1476} MOTIF: lysine residue (SEVERAL) Thr phosphorylation site {T1174} Ser phosphorylation site {S1249} Thr phosphorylation site {T1270} Ser phosphorylation site {S1275} Ser phosphorylation site {S1302} Thr phosphorylation site {T1328} Ser phosphorylation site {S1333} Ser phosphorylation site {S1371} Ser phosphorylation site {S1401} protein C22orf19 MOTIF: Ser phosphorylation site {S307} Ser phosphorylation site {S312} Ser phosphorylation site {S314} WD repeat protein 58 MOTIF: WD repeat {22-61} WD repeat {74-112} WD repeat {124-165} WD repeat {166-205} WD repeat {215-254} WD repeat {256-293} WD repeat {295-339} THO complex subunit 7 homolog FORM: THO complex subunit 7 homolog MOTIF: coiled coil {75-194} NIF3L1 interaction {105-204}

References

UniProt :accession Q13838

Components

protein C22orf19; NF2/meningioma region protein pK1.3; placental protein 39.2 (THOC5, KIAA0983) THO complex subunit 1 (Tho1, nuclear matrix protein p84, THOC1, HPR1) THO complex subunit 2 (Tho2, THOC2) THO complex subunit 7 homolog (Ngg1-interacting factor 3-like protein 1-binding protein 1, THOC7, NIF3L1BP1) WD repeat protein 58 (THO complex subunit 6 homolog, THOC6, WDR58, PSEC0006)