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thioredoxin-like protein 5; 14 kD thioredoxin-related protein; protein 42-9-9 (TXNL5, TRP14, TXNDC17)
Function:
1) disulfide reductase
2) reversible oxidation of its active center dithiol to a disulfide
3) dithiol-disulfide exchange reactions
4) modulates TNF-alpha signaling & NF-kappa-B activation
5) has peroxidase activity
6) elimination of cellular hydrogen peroxide (putative)
7) interacts with TRXR1 & DNCL1
- oxidized protein is reduced by TRXR1
Structure:
1) belongs to the thioredoxin family
2) contains 1 thioredoxin domain
Compartment: cytoplasm
Expression: ubiquitously expressed in cell lines
General
oxidoreductase
thioredoxin-like protein
Properties
SIZE: MW = 14 kD
entity length = 123 aa
COMPARTMENT: cytoplasm
MOTIF: thioredoxin domain
SITE: 41-123
MOTIF: cysteine residue {C43}
MODIFICATION: cysteine residue {C46}
cysteine residue {C43}
cysteine residue {C46}
cysteine residue {C46}
MODIFICATION: cysteine residue {C43}
Database Correlations
UniProt Q9BRA2
Pfam PF06110
References
UniProt :accession Q9BRA2