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thiamin pyrophosphokinase 1; hTPK1; placental protein 20; PP20; thiamine pyrophosphokinase 1 (TPK1)
Function:
1) thiamine pyrophosphate biosynthesis
2) phosphorylation of thiamine to thiamine pyrophosphate
ATP + thiamine AMP + thiamine diphosphate
Structure: homodimer
Expression:
- expressed in heart, kidney, testis, small intestine & peripheral blood leukocytes
Interactions
molecular events
General
kinase or ATP-phosphotransferase
placental protein
Properties
SIZE: entity length = 243 aa
MW = 27 kD
COMPARTMENT: cellular compartment
CELL: unspecified cell type
WITHIN: placenta
MOTIF: kinase domain
MOTIF: ATP-binding site
NAME: ATP-binding site
Database Correlations
OMIM 606370
UniProt Q9H3S4
PFAM correlations
Entrez Gene 27010
Kegg hsa:27010
ENZYME 2.7.6.2
References
UniProt :accession Q9H3S4