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thiamine transporter 2 (ThTr-2, ThTr2, solute carrier family 19 member 3, SLC19A3)
Function:
- mediates high affinity thiamine uptake, via proton anti-port
- no folate transport activity
Structure:
- belongs to the reduced folate carrier transporter family
Compartment: membrane
Expression:
- widely expressed
- most abundant in placenta, kidney, liver
Pathology:
- defects in SLC19A3 are the cause of biotin-responsive basal ganglia disease
General
glycoprotein
solute carrier family 19 (SLC19, SLC19A)
transmembrane 12 protein
Properties
SIZE: MW = 56 kD
entity length = 496 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-7}
transmembrane domain {8-28}
exoplasmic loop {29-53}
MOTIF: N-glycosylation site {N45}
transmembrane domain {54-74}
cytoplasmic loop {75-81}
transmembrane domain {82-102}
exoplasmic loop {103-110}
transmembrane domain {111-131}
cytoplasmic loop {132-144}
transmembrane domain {145-165}
exoplasmic loop {166-169}
MOTIF: N-glycosylation site {N166}
transmembrane domain {170-190}
cytoplasmic loop {191-282}
transmembrane domain {283-303}
exoplasmic loop {304-316}
transmembrane domain {317-337}
cytoplasmic loop {338-342}
transmembrane domain {343-363}
exoplasmic loop {364-375}
transmembrane domain {376-396}
cytoplasmic loop {397-405}
transmembrane domain {406-426}
exoplasmic loop {427-434}
transmembrane domain {435-455}
cytoplasmic domain {456-496}
Database Correlations
OMIM correlations
UniProt Q9BZV2
Pfam PF01770
References
UniProt :accession Q9BZV2