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transforming growth factor beta-3; TGF-beta-3 (TGFB3)
Function:
- role in embryogenesis & cell differentiation
- interacts with ASPN
Structure:
- homodimer, disulfide-linked.
- belongs to the TGF-beta family
Compartment: secreted
Pathology:
- defects in TGFB3 are a cause of familial arrhythmogenic right ventricular dysplasia type 1
General
glycoprotein
transforming growth factor [TGF]-beta
Properties
CONFIGURATION:
dimer
SIZE: entity length = 412 aa
MW = 47 kD
COMPARTMENT:
extracellular compartment
MOTIF:
signal sequence {1-20}
N-glycosylation site {N74}
N-glycosylation site {N135}
N-glycosylation site {N142}
Cell attachment site {261-263}
cysteine residue {C307}
MODIFICATION: cysteine residue {C316}
cysteine residue {C315}
MODIFICATION: cysteine residue {C378}
cysteine residue {C316}
MODIFICATION: cysteine residue {C307}
cysteine residue {C344}
MODIFICATION: cysteine residue {C409}
cysteine residue {C348}
MODIFICATION: cysteine residue {C411}
cysteine residue {C377}
MODIFICATION: cysteine residue {C-INTERCHAIN }
cysteine residue {C378}
MODIFICATION: cysteine residue {C315}
cysteine residue {C409}
MODIFICATION: cysteine residue {C344}
cysteine residue {C411}
MODIFICATION: cysteine residue {C348}
SECRETED-BY:
platelet
macrophage
monocyte
T-cell
endothelial cell
fibroblast
Database Correlations
OMIM correlations
UniProt P10600
PFAM correlations
Entrez Gene 7043
Kegg hsa:7043
References
- UniProt :accession P10600
- GeneReviews
http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/TGFB3
- NIEHS-SNPs
http://egp.gs.washington.edu/data/tgfb3/
- SeattleSNPs
http://pga.gs.washington.edu/data/tgfb3/
- Wikipedia; Note: TGF beta-3 entry
http://en.wikipedia.org/wiki/TGF_beta_3
- Sporn MB, Roberts AB.
Interactions of retinoids and transforming growth factor-beta
in regulation of cell differentiation and proliferation.
Mol Endocrinol. 1991 Jan;5(1):3-7. Review.
PMID: 2017191
- Entrez Gene :accession 7043