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transforming growth factor beta-2; TGF-beta-2; BSC-1 cell growth inhibitor; Cetermin; Glioblastoma-derived T-cell suppressor factor; G-TSF; polyergin (TGFB2)
Function:
- suppressive effects on interleukin-2 dependent T-cell growth
- interacts with ASPN
Structure:
- homodimer, disulfide-linked
- belongs to the TGF-beta family
Compartment: secreted
Alternative splicing: named isoforms=2; A, B
Pathology:
- chromosomal translocation t(1;7)(q41;p21) involving TGFB2 is with HDAC9 is found in a family with Peters anomaly
Related
TGF-beta 2 gene
General
glycoprotein
transforming growth factor [TGF]-beta
Properties
CONFIGURATION:
dimer
SIZE: entity length = 414 aa
MW = 48 kD
COMPARTMENT:
extracellular compartment
MOTIF:
signal sequence {1-19}
N-glycosylation site {N72}
N-glycosylation site {N140}
N-glycosylation site {N241}
cysteine residue {C309}
MODIFICATION: cysteine residue {C318}
cysteine residue {C317}
MODIFICATION: cysteine residue {C380}
cysteine residue {C318}
MODIFICATION: cysteine residue {C309}
cysteine residue {C346}
MODIFICATION: cysteine residue {C411}
cysteine residue {C350}
MODIFICATION: cysteine residue {C413}
cysteine residue {C379}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C380}
MODIFICATION: cysteine residue {C317}
cysteine residue {C411}
MODIFICATION: cysteine residue {C346}
cysteine residue {C413}
MODIFICATION: cysteine residue {C350}
SECRETED-BY:
platelet
macrophage
monocyte
T-cell
endothelial cell
fibroblast
Database Correlations
OMIM 190220
UniProt P61812
PFAM correlations
Entrez Gene 7042
Kegg hsa:7042
References
- UniProt :accession P61812
- NIEHS-SNPs
http://egp.gs.washington.edu/data/tgfb2/
- Wikipedia; Note: TGF beta-2 entry
http://en.wikipedia.org/wiki/TGF_beta_2
- Sporn MB, Roberts AB.
Interactions of retinoids and transforming growth factor-beta
in regulation of cell differentiation and proliferation.
Mol Endocrinol. 1991 Jan;5(1):3-7. Review.
PMID: 2017191
- Entrez Gene :accession 7042