TFTC-HAT complex (TATA-binding protein-free TAF complex, TBP-free TAFII complex, TFTC)

Structure: - consists of: - TAF5L, TAF6L, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, GCN5L2/GCN5, TAF10, TRRAP

Properties

COMPARTMENT: cell nucleus SUBUNITS: TAF5-like RNA polymerase II p300 COMPARTMENT: cell nucleus MOTIF: WD repeat {266-305} WD repeat {340-379} WD repeat {382-421} WD repeat {424-463} WD repeat {466-505} WD repeat {508-547} TAF6-like RNA polymerase II p300 COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S85} transcriptional adapter 3-like COMPARTMENT: cell nucleus MOTIF: coiled coil {40-69} coiled coil {367-407} transcription initiation protein SPT3 homolog COMPARTMENT: cell nucleus transcription initiation factor TFIID subunit 2 COMPARTMENT: cell nucleus MOTIF: lysine-rich region {600-603} MOTIF: lysine residue (SEVERAL) histidine-rich region {1143-1171} MOTIF: histidine residue (SEVERAL) lysine-rich region {1155-1178} MOTIF: lysine residue (SEVERAL) Ser phosphorylation site {S1194} Ser phosphorylation site {S1196} Ser phosphorylation site {S1198} transcription initiation factor TFIID subunit 4 COMPARTMENT: cell nucleus MOTIF: histidine-rich region {39-42} MOTIF: histidine residue (SEVERAL) alanine-rich region {52-57} MOTIF: alanine residue (SEVERAL) glycine-rich region {98-101} alanine-rich region {142-148} MOTIF: alanine residue (SEVERAL) proline-rich region SITE: 270-277 MOTIF: proline residue (SEVERAL) alanine-rich region {333-339} MOTIF: alanine residue (SEVERAL) TAFH {590-687} MOTIF: proline-rich region SITE: 682-685 MOTIF: proline residue (SEVERAL) alanine-rich region {810-815} MOTIF: alanine residue (SEVERAL) transcription initiation factor TFIID subunit 5 COMPARTMENT: cell nucleus MOTIF: glycine-rich region {46-49} LisH {92-124} lysine-rich region {399-407} MOTIF: lysine residue (SEVERAL) WD repeat {468-507} WD repeat {541-580} WD repeat {583-624} WD repeat {625-666} WD repeat {667-706} WD repeat {709-748} general control of amino acid synthesis protein 5-like 2 COMPARTMENT: cell nucleus MOTIF: N-acetyltransferase {503-656} Tyr phosphorylation site {Y734} bromodomain {745-815} transcription initiation factor TFIID subunit 10 COMPARTMENT: cell nucleus MOTIF: [KR]-[STA]-K {187-189} transformation/transcription domain-associated protein MOTIF: proline-rich region SITE: 485-526 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S1628} TP53 interaction {2010-2388} MOTIF: nuclear translocation signal {2047-2062} Ser phosphorylation site {S2051} Ser phosphorylation site {S2077} Thr phosphorylation site {T2333} Thr phosphorylation site {T2601} FAT domain NAME: FAT domain SITE: 2704-3275 MOTIF: Tyr phosphorylation site binding site FOR-BINDING-OF: Paxillin PI3K/PI4K {3528-3826} FATC {3827-3859}

References

UniProt :accession O75486

Components

general control of amino acid synthesis protein 5-like 2; histone acetyltransferase GCN5; hsGCN5; STAF97 (GCN5L2, GCN5, HGCN5, KAT2A) TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kD subunit 5L; PCAF-associated factor 65-beta; PAF65-beta (TAF5L, PAF65B) TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kD subunit 6L; PCAF-associated factor 65-alpha; PAF65-alpha (TAF6L PAF65A) transcription initiation factor TFIID subunit 10; STAF28; transcription initiation factor TFIID 30 kD subunit; TAF(II)30; TAFII-30; TAFII30 (TAF10, TAF2A, TAF2H, TAFII30) transcription initiation factor TFIID subunit 2; 150 kD cofactor of initiator function; RNA polymerase II TBP-associated factor subunit B; TBP-associated factor 150 kDa; transcription initiation factor TFIID 150 kD subunit; TAF(II)150; TAFII-150; TAFII150 (TAF2, CIF150, TAF2B) transcription initiation factor TFIID subunit 4; p136TFIID; RNA polymerase II TBP-associated factor subunit C; TBP-associated factor 4; transcription initiation factor TFIID 130 kD subunit; TAF(II)130; TAFII-130; TAFII130; transcription initiation factor TFIID 135 kD subunit; TAF(II)135; TAFII-135; TAFII135 (TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135) transcription initiation factor TFIID subunit 5; p100TFIID; transcription initiation factor TFIID 100 kD subunit; TAF(II)100; TAFII-100; TAFII100 (TAF5, TAF2D) transcription initiation protein SPT3 homolog (SPT3-like protein, SUPT3H, SPT3) transcriptional adapter 3-like; ADA3-like protein; ADA3 homolog; hADA3 (TADA3L, ADA3, TADA3) transformation/transcription domain-associated protein; 350/400 kD PCAF-associated factor; PAF350/400; STAF40; tra1 homolog (TRRAP, PAF400)