TFIIIB

Function: - the TFIIIB complex has two activities, alpha & beta - the TFIIIB-alpha & TFIIIB-beta activities are required for transcription of genes with TFIIIC-bound internal promoters & PSE transcription factor-bound external promoters, respectively - TFIIIB-alpha inhibits transcription by RNA polymerase 3 via its phosphorylation by CK2 - YY1 facilitates formation of TFIIIB-alpha activity complex Structure: - the TFIIIB-alpha activity complex is composed of TBP, BDP1, & a complex containing both BRF2 & at least 4 stably associated proteins - the TFIIIB-beta activity complex is composed of TBP, BDP1, & BRF1

General

molecular complex transcription factor (TF)

Properties

COMPARTMENT: cell nucleus SUBUNITS: TATA-box-binding protein COMPARTMENT: cell nucleus MOTIF: glutamine-rich region {55-95} MOTIF: glutamine residue (SEVERAL) consensus repeat {165-241} consensus repeat {255-332} transcription factor IIIB 90 kD subunit MOTIF: Zinc finger NAME: Zinc finger SITE: 2-33 EFFECTOR-BOUND: Zn+2 MOTIF: Zn+2-binding site SITE: 6-6 Zn+2-binding site SITE: 9-9 Zn+2-binding site SITE: 25-25 Zn+2-binding site SITE: 28-28 consensus repeat {91-172} consensus repeat {185-269} Ser phosphorylation site {S433} Ser phosphorylation site {S553} transcription factor IIIB 50 kD subunit COMPARTMENT: cell nucleus MOTIF: Zinc finger NAME: Zinc finger SITE: 2-36 EFFECTOR-BOUND: Zn+2 MOTIF: Zn+2-binding site SITE: 7-7 Zn+2-binding site SITE: 10-10 Zn+2-binding site SITE: 28-28 Zn+2-binding site SITE: 31-31 consensus repeat {72-157} consensus repeat {173-249}

References

UniProt :accession A6H8Y1

Components

TATA-box-binding protein; TATA sequence-binding protein; TATA-binding factor; TATA-box factor; transcription initiation factor TFIID TBP subunit; p38TFIID; p38tau (TBP, GTF2D1, TF2D, TFIID) transcription factor IIIB 50 kD subunit (TFIIIB50, hTFIIIB50, B-related factor 2, BRF-2, hBRFU, BRF2, BRFU, PRO1470) transcription factor IIIB 90 kD subunit; TFIIIB90; hTFIIIB90; B-related factor 1; BRF-1; hBRF; TAF3B2; TATA box-binding protein-associated factor, RNA polymerase III, subunit 2 (BRF1, BRF, GTF3B, TAF3B2, TAF3C)