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transcription factor IIIA; factor A (TFIIIA, GTF3A)
Function:
- interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, & is required for correct transcription of these genes by RNA polymerase 3
- also binds the transcribed 5S RNA's
- may initiate transcription of the 5S ribosomal RNA gene & maintain the stability of transcription of other genes
Structure: contains 9 C2H2-type Zn+2 fingers
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression: ubiquitous
Note:
- uncertain whether Met-1 is the initiator
- based on the lack of an in-frame AUG codon, mammalian TFIIIA may be translated from this non-AUG initiation site, which has a good Kozak context & which is well conserved among mammals
Interactions
molecular events
General
C2H2 type zinc finger protein
DNA-binding protein
transcription factor (TF)
Properties
SIZE: entity length = 365 aa
MW = 42 kD
COMPARTMENT: cell nucleus
MOTIF: Zn finger C2H2-type
SITE: 40-64
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 70-94
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 100-125
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 132-154
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 162-186
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 189-213
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 217-239
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 246-271
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 277-301
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 600860
UniProt Q92664
Pfam PF00096
References
- Molecular Cell Biology (2nd ed) Darnell J; Lodish H
& Baltimore D (eds), Scientific American Books,
WH Freeman, NY 1990, pg 277
- UniProt :accession Q92664