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transcription initiation factor IIE subunit beta; TFIIE-beta; general transcription factor IIE subunit 2; p34TFIIE (GTF2E2, TF2E2)
Function:
- recruits TFIIH to the initiation complex & stimulates RNA polymerase 2 C-terminal domain kinase & DNA-dependent ATPase activities of TFIIH
- both TFIIH & TFIIE are required for promoter clearance by RNA polymerase 2
- interacts with FACT subunit SUPT16H
Structure:
- TFIIE is a tetramer of 2 TFIIE-alpha & 2 TFIIE-beta chains
- belongs to the TFIIE beta subunit family
- contains 1 TFIIE beta DNA-binding domain
Compartment: nucleus
General
DNA-binding protein
transcription factor IIE subunit
Properties
SIZE: entity length = 291 aa
MW = 33 kD
COMPARTMENT: cell nucleus
MOTIF: serine-rich region {26-36}
MOTIF: serine residue (SEVERAL)
lysine-rich region {37-42}
MOTIF: lysine residue (SEVERAL)
DNA-binding motif
SITE: 66-146
lysine-rich region {251-271}
MOTIF: lysine residue (SEVERAL)
Database Correlations
OMIM correlations
UniProt P29084
Pfam PF02186
Entrez Gene 2961
Kegg hsa:2961
References
- Drapkin R, Reinberg D.
The multifunctional TFIIH complex and transcriptional control.
Trends Biochem Sci. 1994 Nov;19(11):504-8. Review.
PMID: 7855896
- UniProt :accession P29084
Component-of
transcription factor IIE (TFIIE)