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transcription factor IIA
Function:
- component of the transcription machinery of RNA polymerase 2
- role in transcriptional activation
- TFIIA in a complex with TBP mediates transcriptional activity
- TFIIA facilitates binding of TFIID to the TATA box, generating the TFIID/TFIIA (DA) complex
Structure:
- TFIIA is a heterodimer of the large unprocessed subunit 1 & a small subunit gamma
- originally believed to be a heterotrimer of an alpha (p35), a beta (p19) & a gamma subunit (p12)
General
general transcription factor (basal transcription factor, transcription initiation factor)
multisubunit protein
Properties
COMPARTMENT: cell nucleus
SUBUNITS: transcription initiation factor IIA alpha
COMPARTMENT: cell nucleus
FORM: transcription initiation factor IIA alpha
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
glutamine-rich region {71-80}
MOTIF: glutamine residue (SEVERAL)
histidine-rich region {81-87}
MOTIF: histidine residue (SEVERAL)
proteolytic site {274-275}
Ser phosphorylation site {S280}
Ser phosphorylation site {S281}
Ser phosphorylation site {S316}
Ser phosphorylation site {S321}
transcription initiation factor IIA beta
COMPARTMENT: cell nucleus
FORM: transcription initiation factor IIA beta
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
glutamine-rich region {71-80}
MOTIF: glutamine residue (SEVERAL)
histidine-rich region {81-87}
MOTIF: histidine residue (SEVERAL)
proteolytic site {274-275}
Ser phosphorylation site {S280}
Ser phosphorylation site {S281}
Ser phosphorylation site {S316}
Ser phosphorylation site {S321}
transcription initiation factor IIA subunit 2
References
- Ha I, Lane WS, Reinberg D.
Cloning of a human gene encoding the general transcription
initiation factor IIB.
Nature. 1991 Aug 22;352(6337):689-95.
PMID: 1876184
- UniProt :accession P52655
Component-of
transcriptional initiation complex
Components
transcription initiation factor IIA alpha (TFIIA-alpha, TFIIA p35 subunit)
transcription initiation factor IIA beta (TFIIA p19 subunit)
transcription initiation factor IIA subunit 2; general transcription factor IIA subunit 2; TFIIA p12 subunit; TFIIA-12; TFIIAS; transcription initiation factor IIA gamma chain; TFIIA-gamma (GTF2A2 TF2A2)