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tezepelumab-ekko (Tezspire)

Indications: - uncontrolled asthma in adults (FDA-approved for severe asthma) - adjunctive treatment with long-acting beta-agonists & inhaled glucocorticoids - may improve sleep [6] - added to SQ immunotherapy for allergic rhinitis due to cat allergies [4] * reduces exacerbations, improves lung function, controls asthma control, & improves health-related quality of life in patients with severe, uncontrolled asthma [2] Dosage: - 70 mg SQ every 4 weeks - 210 mg SQ every 4 weeks - 280 mg SQ every 2 weeks Mechanism of action: - inhibits thymic stromal lymphopoietin (TSLP)

Interactions

drug adverse effects of pharmaceutical monoclonal antibodies

General

pharmaceutical monoclonal antibody

References

  1. Corren J, Parnes JR, Wang L et al Tezepelumab in Adults with Uncontrolled Asthma N Engl J Med 2017; 377:936-946. September 7, 2017 PMID: 28877011 http://www.nejm.org/doi/full/10.1056/NEJMoa1704064 - Bel EH. Moving upstream - Anti-TSLP in persistent uncontrolled asthma. N Engl J Med 2017 Sep 7; 377:989. PMID: 28877024 http://www.nejm.org/doi/10.1056/NEJMe1709519
  2. Menzies-Gow A, Corren J, BourdinA et al Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma. N Engl J Med 2021; 384:1800-1809. May 13 PMID: 33979488 https://www.nejm.org/doi/full/10.1056/NEJMoa2034975
  3. Helio FDA approves tezepelumab for severe asthma https://www.healio.com/news/pulmonology/20211220/fda-approves-tezepelumab-for-severe-asthma - Larkin HD News From the Food and Drug Administration Therapy Approved for All Types of Severe Asthma JAMA. 2022;327(9):805 PMID: 35230413 https://jamanetwork.com/journals/jama/fullarticle/2789564
  4. Janeczko JL Add Tezepelumab to SCIT to Improve Cat Allergy Symptoms? Medscape. Nov 18, 2022 https://www.medscape.com/viewarticle/984335
  5. Corren J, Menzies-Gow A, Chupp G, et al. Efficacy of Tezepelumab in Severe, Uncontrolled Asthma: Pooled Analysis of the PATHWAY and NAVIGATOR Clinical Trials. Am J Respir Crit Care Med. 2023 Jul 1;208(1):13-24. PMID: 37015033
  6. Kahn K Tezepelumab for Severe Asthma Improves the Odds of a Good Night's Sleep. However, analysis did not control for treatments of comorbid sleep disorders, expert points out. MedPage Today October 11, 2024 https://www.medpagetoday.com/meetingcoverage/chest/112363