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E3 ubiquitin-protein ligase TTC3; protein DCRR1; RING finger protein 105; TPR repeat protein D; tetratricopeptide repeat protein 3; TPR repeat protein 3 (TTC3, DCRR1, RNF105, TPRD)
Function:
- E3 ubiquitin-protein ligase that mediates ubiquitination & subsequent degradation of phosphorylated Akt (AKT1, AKT2 & AKT3) in the nucleus
- acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation
- catalyzes the formation of Lys-48-polyubiquitin chains
- may play a role in neuronal differentiation
- inhibition via its interaction with CIT
- protein modification; protein ubiquitination
- phosphorylation on Ser-378 by Akt is required for ubiquitin ligase activity
- interacts (when phosphorylated on Ser-378) with AKT1, AKT2 & AKT3 (when phosphorylated)
- interacts with CIT
Structure:
- contains 1 RING-type Zn+2 finger
- contains 4 TPR repeats
Compartment: nucleus
Alternative splicing: named isoforms=3
Expression: found in all tissues examined
General
nuclear protein
phosphoprotein
tetratricopeptide repeat protein
E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein
zinc finger protein
Properties
SIZE: entity length = 2025 aa
MW = 230 kD
COMPARTMENT: cell nucleus
MOTIF: tetratricopeptide repeat {231-264}
tetratricopeptide repeat {266-298}
Ser phosphorylation site {S378}
serine-rich region {453-456}
MOTIF: serine residue (SEVERAL)
tetratricopeptide repeat {536-572}
tetratricopeptide repeat {576-609}
lysine-rich region {1018-1029}
MOTIF: lysine residue (SEVERAL)
lysine-rich region {1020-1029}
MOTIF: lysine residue (SEVERAL)
lysine-rich region {1172-1185}
MOTIF: lysine residue (SEVERAL)
lysine-rich region {1563-1579}
MOTIF: lysine residue (SEVERAL)
lysine-rich region {1899-1902}
MOTIF: lysine residue (SEVERAL)
RING-finger {1957-1997}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Database Correlations
OMIM 602259
UniProt P53804
Pfam PF00097
Entrez Gene 7267
Kegg hsa:7267
References
UniProt :accession P53804