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tetraspanin-33 (transmembrane 4 superfamily member 33, proerythroblast new membrane, penumbra, hPen, Tspan-33, TSPAN33)
Function:
- role in normal erythropoiesis
- role in the differentiation of erythroid progenitors
Structure:
- homodimer, disulfide-linked
- belongs to the tetraspanin (TM4SF) family
Compartment: membrane
Expression: predominantly expressed in erythroblasts
General
glycoprotein
tetraspanin (transmembrane-4-superprotein)
Properties
SIZE: MW = 32 kD
entity length = 283 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-24}
transmembrane domain {25-45}
exoplasmic loop {46-64}
transmembrane domain {65-85}
cytoplasmic loop {86-96}
transmembrane domain {97-117}
exoplasmic loop {118-235}
MOTIF: N-glycosylation site {N172}
transmembrane domain {236-256}
cytoplasmic domain {257-283}
Database Correlations
UniProt Q86UF1
Pfam PF00335
References
UniProt :accession Q86UF1