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tetraspanin-2; Tspan-2; tetraspan NET-3 (TSPAN2)
Function:
- may play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia
- may also function in stabilizing the mature sheath
Structure: belongs to the tetraspanin (TM4SF) family
Compartment: membrane (probable)
General
glycoprotein
tetraspanin (transmembrane-4-superprotein)
Properties
SIZE: entity length = 221 aa
MW = 24 kD
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-13}
transmembrane domain {14-34}
exoplasmic loop {35-54}
transmembrane domain {55-75}
cytoplasmic loop {76-90}
transmembrane domain {91-111}
exoplasmic loop {112-188}
MOTIF: N-glycosylation site {N139}
transmembrane domain {189-209}
cytoplasmic domain {210-221}
Database Correlations
OMIM 613133
UniProt O60636
Pfam PF00335
Entrez Gene 10100
Kegg hsa:10100
References
UniProt :accession O60636