testis-specific Y-encoded-like protein 2 (TSPY-like 2, differentially expressed nucleolar TGF-beta1 target protein, cell division autoantigen 1, cutaneous T-cell lymphoma-associated antigen se20-4, CTCL tumor antigen se20-4, nuclear protein of 79 kD, NP79, TSPYL2, CDA1, DENTT, TSPX, HRIHFB2216)

Function: - part of the CASK/TRB1/TSPYL2 transcriptional complex - may inhibit cell proliferation by inducing p53-dependent CDKN1A expression - interacts with histones - interacts with CASK - phosphorylation at Ser-20 &/or Thr-340 impairs function on cell proliferation (probable) Structure: - belongs to the nucleosome assembly protein (NAP) family Compartment: - nucleus, cytoplasm (putative) - enriched in transcriptionally active regions of chromatin in neurons (putative) Expression: - ubiquitously expressed - highest levels in brain, testis & heart - lowest levels in liver & pancreas - up-regulated in growth-arrested T-cells - induced by TGFB1 & all-trans retinoic acid in lung cancer cells (at protein level) - synaptic activity down-regulates TSPYL2 protein levels by inducing rapid proteasomal degradation (putative) Note: subject to X inactivation

General

nuclear protein phosphoprotein Y chromosome protein

Properties

SIZE: MW = 79 kD entity length = 693 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: proline-rich region SITE: 4-75 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S16} Ser phosphorylation site {S17} Ser phosphorylation site {S20} arginine-rich region {180-211} MOTIF: arginine residue (SEVERAL) Thr phosphorylation site {T340}

Database Correlations

UniProt Q9H2G4 Pfam PF00956

References

UniProt :accession Q9H2G4