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testis-specific protease-like protein 50 (TSP50, PRSS50)
Structure:
- belongs to the peptidase S1 family
- contains 1 peptidase S1 domain
- Thr-310 is present instead of the conserved Ser which is expected to be an active site residue, thus probably not an active protease
Expression:
- testis specific
Pathology:
- differentially expressed in some breast cancer tissues
Genetics:
- DNA hypomethylation is accompanied by the expression of the gene in the testis
General
glycoprotein
secreted protein
testis-specific protein
Properties
SIZE: MW = 43 kD
entity length = 385 aa
COMPARTMENT: cellular compartment
CELL: unspecified cell type
WITHIN: testis
MOTIF: signal sequence {1-39}
S1 domain {93-358}
MOTIF: N-glycosylation site {N133}
cysteine residue {C138}
MODIFICATION: cysteine residue {C154}
cysteine residue {C154}
MODIFICATION: cysteine residue {C138}
cysteine residue {C240}
MODIFICATION: cysteine residue {C316}
cysteine residue {C273}
MODIFICATION: cysteine residue {C296}
N-glycosylation site {N279}
cysteine residue {C296}
MODIFICATION: cysteine residue {C273}
cysteine residue {C306}
MODIFICATION: cysteine residue {C334}
cysteine residue {C316}
MODIFICATION: cysteine residue {C240}
cysteine residue {C334}
MODIFICATION: cysteine residue {C306}
Database Correlations
OMIM 607950
UniProt Q9UI38
Pfam PF00089
References
UniProt :accession Q9UI38