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dual specificity testis-specific protein kinase 2; testicular protein kinase 2 (TESK2)
Function:
- dual specificity protein kinase activity catalyzing autophosphorylation & phosphorylation of exogenous substrates on both Ser/Thr & Tyr
- phosphorylates cofilin at Ser-3
- may play an role in spermatogenesis
- activated by autophosphorylation on Ser-219
ATP + a protein = ADP + a phosphoprotein
Cofactor: Mg+2, Mn+2 (putative)
Structure:
- belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family
- contains 1 protein kinase domain
Compartment: nucleus
Alternative splicing: named isoforms=3
Expression:
- predominantly expressed in testis & prostate
- found predominantly in non-germinal Sertoli cells
General
nuclear protein
testicular protein kinase (testis-specific protein kinase)
Properties
SIZE: entity length = 571 aa
MW = 64 kD
COMPARTMENT: cell nucleus
MOTIF: kinase domain
SITE: 58-313
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 64-72
ATP-binding site
NAME: ATP-binding site
SITE: 87-87
aspartate residue {D176}
Ser phosphorylation site {S219}
STATE: active state
Database Correlations
OMIM 604746
UniProt Q96S53
Pfam PF07714
Entrez Gene 10420
Kegg hsa:10420
ENZYME 2.7.12.1
References
UniProt :accession Q96S53