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testican-3 (SPARC/osteonectin, CWCV, & Kazal-like domains proteoglycan 3, SPOCK3, TICN3, UNQ409/PRO771)
Function:
1) role in neurogenesis (putative)
2) inhibits processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP & MT3-MMP
3) may interfere with tumor invasion
Structure:
- contains chondroitin sulfate & heparan sulfate O-linked oligosaccharides
- contains 1 Kazal-like domain
- contains 1 thyroglobulin type-1 domain
Compartment: extracellular matrix
Alternative splicing: named isoforms=3
Expression: expressed in brain
General
glycoprotein
matrix protein
Properties
SIZE: MW = 49 kD
entity length = 436 aa
COMPARTMENT: extracellular matrix
MOTIF: signal sequence {1-21}
cysteine residue {C90}
MODIFICATION: cysteine residue {C101}
cysteine residue {C95}
MODIFICATION: cysteine residue {C111}
cysteine residue {C101}
MODIFICATION: cysteine residue {C90}
cysteine residue {C111}
MODIFICATION: cysteine residue {C95}
Kazal-type serine protease inhibitor domain {139-184}
MOTIF: cysteine residue {X+0}
MODIFICATION: cysteine residue {X+X4}
cysteine residue {X+X1}
MODIFICATION: cysteine residue {X+X3}
cysteine residue {X+X2}
MODIFICATION: cysteine residue {X+X5}
cysteine residue {X+X3}
MODIFICATION: cysteine residue {X+X1}
cysteine residue {X+X4}
MODIFICATION: cysteine residue {X+0}
cysteine residue {X+X5}
MODIFICATION: cysteine residue {X+X2}
cysteine residue {C139}
MODIFICATION: cysteine residue {C169}
cysteine residue {C142}
MODIFICATION: cysteine residue {C162}
cysteine residue {C151}
MODIFICATION: cysteine residue {C183}
cysteine residue {C162}
MODIFICATION: cysteine residue {C142}
cysteine residue {C169}
MODIFICATION: cysteine residue {C139}
cysteine residue {C183}
MODIFICATION: cysteine residue {C151}
FOR-BINDING-OF: serine protease
Thyroglobulin type-1 {314-380}
MOTIF: cysteine residue {C317}
MODIFICATION: cysteine residue {C341}
cysteine residue {C341}
MODIFICATION: cysteine residue {C317}
cysteine residue {C352}
MODIFICATION: cysteine residue {C359}
cysteine residue {C359}
MODIFICATION: cysteine residue {C352}
cysteine residue {C361}
MODIFICATION: cysteine residue {C380}
cysteine residue {C380}
MODIFICATION: cysteine residue {C361}
Ser glycosylation site {S387}
Ser glycosylation site {S392}
Database Correlations
OMIM 607989
UniProt Q9BQ16
PFAM correlations
References
UniProt :accession Q9BQ16