Search
teratocarcinoma-derived growth factor 3; cripto-3 growth factor; epidermal growth factor-like cripto protein CR3; teratocarcinoma-derived growth factor 1 pseudogene 3 (TDGF1P3, CRIPTO3, TDGF2, TDGF3)
Function:
- may play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm
- activates the nodal-dependent signaling pathway
Structure: contains 1 EGF-like domain
Compartment: cell membrane
Expression:
- expressed weakly in lung, colon & breast
- expressed strongly in primary cancer tissues; lung cancer & colon cancer
Note:
- could be the product of a pseudogene
- the TDGF3 locus has characteristics of a retrotransposon, including lack of introns & a poly(A) sequence
General
glycoprotein
growth factor
Properties
SIZE: entity length = 188 aa
MW = 21 kD
MOTIF: EGF domain {78-107}
MOTIF: N-glycosylation site {N79}
cysteine residue {C82}
MODIFICATION: cysteine residue {C89}
cysteine residue {C83}
MODIFICATION: cysteine residue {C95}
cysteine residue {C89}
MODIFICATION: cysteine residue {C82}
cysteine residue {C95}
MODIFICATION: cysteine residue {C83}
cysteine residue {C97}
MODIFICATION: cysteine residue {C106}
cysteine residue {C106}
MODIFICATION: cysteine residue {C97}
cysteine residue {C115}
MODIFICATION: cysteine residue {C133}
cysteine residue {C128}
MODIFICATION: cysteine residue {C149}
cysteine residue {C131}
MODIFICATION: cysteine residue {C140}
cysteine residue {C133}
MODIFICATION: cysteine residue {C115}
cysteine residue {C140}
MODIFICATION: cysteine residue {C131}
cysteine residue {C149}
MODIFICATION: cysteine residue {C128}
Database Correlations
OMIM 187395
UniProt P51864
Pfam PF09443
References
UniProt :accession P51864