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Tensilon test; edrophonium test
Indications:
- evaluation for myasthenia gravis
Procedure:
1) discontinue all anticholinesterase medications at least 8 hours prior to administration of edrophonium
2) draw 10 mg of edrophonium into a syringe
3) 2 mg test IV over 15-30 seconds
a) if a cholinergic reaction occurs, stop infusion
b) administer 0.5 mg of atropine IV
4) 8 mg IV after 45 sec if no response to test dose
5) test may be repeated after 30 minutes
Clinical significance:
- a positive test, i.e. a positive neuromuscular response to edrophonium (i.e. reversal of ptosis) is consistent a diagnosis of myasthenia gravis
Related
edrophonium (Tensilon)
General
provocative clinical test