telomeric repeat-binding factor 2-interacting protein 1 (TRF2-interacting telomeric protein Rap1, hRap1, TERF2IP, RAP1, PP8000)

Function: 1) telomere length regulation 2) recruited to telomeres by TRF2 3) does not directly bind to DNA itself Structure: homodimer Compartment: - nucleus - colocalizes with telomeric DNA in interphase & metaphase cells Expression: ubiquitous, highly expressed

General

nuclear protein phosphoprotein

Properties

SIZE: MW = 44 kD entity length = 399 aa COMPARTMENT: cell nucleus MOTIF: BRCA1 C-terminal (BRCT) motif SITE: 78-101 DNA-binding motif SITE: 128-188 MOTIF: Ser phosphorylation site {S154} Ser phosphorylation site {S203} acidic region {214-304} MOTIF: acidic residue (SEVERAL) nuclear translocation signal {383-399}

Database Correlations

OMIM 605061 UniProt Q9NYB0

References

UniProt :accession Q9NYB0