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telomere analysis

Indications: - evaluation of dyskeratosis congenita [2] Clinical significance: - telomere length may be predictive of serum cholesterol & pulmonary function [2]* - telomere length does not add to the predictive power of chronological age in predicting functional decline [3]* - telomere length does not predict cognitive decline [3]* - leukocyte telomere length is associated with a small risk of increased overall mortality (RR=1.1) & a higher risk of mortality was associated with organ-specific disease (digestive RR=1.3, respiratory RR=1.4, musculoskeletal RR=1.5) [4] - longer leukocyte telomere length is associated alterations in cardiovascular structure & function [7] - higher left ventricular mass - larger ventricular sizes - larger atrial sizes - higher stroke volumes. - longer leukocyte telomere length may be associated with a reduce risk of heart failure (only after accounting for potential confounders) [7] * specimen: saliva Specimen: - peripheral-blood leukocytes - saliva [3] Increases: - green tea may be protective against leukocyte telomere shortening whereas coffee & soft drinks may not [5] Decreases: - leukocyte telomere length decreases with biological aging [6]

Related

subtelomere analysis telomere

General

molecular diagnostic test

References

  1. Loinc
  2. Kelmenson DA, Hanley M (images) Dyskeratosis Congenita. N Engl J Med 2017; 376:1460. April 13, 2017 PMID: 28402761 http://www.nejm.org/doi/full/10.1056/NEJMicm1613081
  3. Brown L, Zhang Y, Mitchel C, Ailshire J. Does Telomere Length Indicate Biological, Physical and Cognitive Health Among Older Adults? Evidence from the Health and Retirement Study. The Journals of Gerontology: Series A, gly001. Jan 16, 2018 PMID: 29346517 http://news.doximity.com/entries/10854905
  4. Schneider CV, Schneider KM, Teumer A et al Association of Telomere Length With Risk of Disease and Mortality. JAMA Intern Med. 2022;182(3):291-300. PMID: 35040871 PMCID: PMC8767489 (available on 2023-01-18) https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2788295
  5. Sohn I, Shin C, Baik I Associations of green tea, coffee, and soft drink consumption with longitudinal changes in leukocyte telomere length. Scientific Reports. 2023. 13:492 PMID: 36627320 PMCID: PMC9832020 Free PMC article https://www.nature.com/articles/s41598-022-26186-y
  6. Muezzinler A, Zaineddin AK, Brenner H. A systematic review of leukocyte telomere length and age in adults. Ageing Res. Rev. 2013. 12:509-519 PMID: 23333817 Review.
  7. Aung N, Wang Q, van Duijvenboden S et al Association of Longer Leukocyte Telomere Length With Cardiac Size, Function, and Heart Failure. JAMA Cardiol. Published online July 26, 2023. PMID: 37494011 https://jamanetwork.com/journals/jamacardiology/fullarticle/2807386