tectorin-alpha (TECTA)

Function: 1) one of the major non-collagenous components of the tectorial membrane 2) may form homomeric filament after self-association or heteromeric filament after association with beta-tectorin Compartment: - cell membrane, lipid-anchor, GPI-anchor - targeted to the apical surface of the inner ear epithelia & proteolytically released into the extracellular compartment Pathology: 1) defects in TECTA are the cause of autosomal dominant non-syndromic sensorineural deafness 8 2) defects in TECTA are the cause of autosomal dominant non-syndromic sensorineural deafness 12 3) defects in TECTA are the cause of autosomal recessive non-syndromic sensorineural deafness 21

Properties

SIZE: MW = 239 kD entity length = 2155 aa COMPARTMENT: extracellular compartment MOTIF: N-glycosylation site {N34} NIDO {163-252} MOTIF: N-glycosylation site {N187} N-glycosylation site {N215} VWFC {260-314} MOTIF: N-glycosylation site {N278} VWFD domain {322-478} MOTIF: N-glycosylation site {N455} N-glycosylation site {N506-N560} (3) TIL 1 {597-650} N-glycosylation site {N670-N687} (2) VWFD domain {713-866} MOTIF: N-glycosylation site {N813} N-glycosylation site {N843} N-glycosylation site {N855} N-glycosylation site {N898-N949} (4) TIL 2 {984-1036} N-glycosylation site {N1048} VWFD domain {1100-1258} MOTIF: N-glycosylation site {N1235} N-glycosylation site {N1364} TIL 3 {1372-1425} VWFD domain {1487-1639} MOTIF: N-glycosylation site {N1538} N-glycosylation site {N1565} N-glycosylation site {N1756-N1794} (3) ZP domain {1805-2059} MOTIF: cysteine residue {*1} MODIFICATION: cysteine residue {*2} cysteine residue {*2} MODIFICATION: cysteine residue {*1} N-glycosylation site {N1851} N-glycosylation site {N1864} N-glycosylation site {N1880} N-glycosylation site {N1920} N-glycosylation site {N1939} glycosyl phosphatidylinositol [GPI] membrane anchor {C-TERMINUS}

Database Correlations

OMIM correlations MORBIDMAP 602574 UniProt O75443 PFAM correlations