tectonic-1 (TECT1, TCTN1)

Function: 1) regulator of Hedgehog 2) required for both activation & inhibition of the Hedgehog pathway in the patterning of the neural tube 3) during neural tube development, required for formation of the most ventral cell types & for full Hedgehog pathway activation 4) modulates Hedgehog signal transduction downstream of SMO & RAB23 (putative) Compartment: secreted Alternative splicing: named isoforms=6

General

glycoprotein secreted protein tectonic protein

Properties

SIZE: MW = 64 kD entity length = 587 aa COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-22} N-glycosylation site {N36} cysteine-rich region {78-97} N-glycosylation site {N295} N-glycosylation site {N528}

Database Correlations

UniProt Q2MV58 Pfam PF07773

References

UniProt :accession Q2MV58