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Teashirt homolog 1; antigen NY-CO-33; serologically defined colon cancer antigen 33 (TSHZ1, SDCCAG33, TSH1)
Function:
- transcriptional regulator involved in developmental processes (putative)
- may act as a transcriptional repressor
- interacts (via homeobox domain) with APBB1 (via PID domain 1) (putative)
Structure:
- belongs to the teashirt C2H2-type Zn+2-finger protein family
- contains 5 C2H2-type Zn+2 fingers
- contains 1 homeobox DNA-binding domain
Compartment: nucleus (probable)
Alternative splicing: named isoforms=2
Expression:
- expressed in brain
Pathology:
- expression is diminished in elderly subjects with Alzheimer disease (post-mortem studies)
- defects in TSHZ1 are the cause of congenital aural atresia
Related
adenocarcinoma of the colon &/or rectum
General
C2H2 type zinc finger protein
transcription factor (TF)
Properties
SIZE: entity length = 1077 aa
MW = 118 kD
COMPARTMENT: cell nucleus
MOTIF: serine-rich region {58-195}
MOTIF: serine residue (SEVERAL)
Zn finger C2H2-type
SITE: 246-270
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 307-331
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 416-440
EFFECTOR-BOUND: Zn+2
homeodomain
SITE: 885-955
Zn finger C2H2-type
SITE: 970-992
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 1037-1060
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM correlations
UniProt Q6ZSZ6
Entrez Gene 10194
Kegg hsa:10194
References
UniProt :accession Q6ZSZ6