Search
TBP-associated factor 172; TAF-172; TAF(II)170; BTAF1 RNA polymerase 2; B-TF2D transcription factor-associated 170-kd; BTAF1; TATA box-binding protein-associated factor RNA polymerase 2 170-kd (TAF172)
Function:
- regulates transcription in association with TATA binding protein (TBP)
- removes TBP from the TATA box in an ATP-dependent manner
- associates with TBP to form B-TFIID. binds DRAP1
Structure:
- belongs to the SNF2/RAD54 helicase family
- contains 8 HEAT repeats
- contains 1 helicase ATP-binding domain
- contains 1 helicase C-terminal domain
Compartment: nucleus
General
HEAT repeat-containing protein (HEATR)
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 1849 aa
MW = 207 kD
COMPARTMENT: cell nucleus
MOTIF: nuclear translocation signal {191-207}
Ser phosphorylation site {S237}
HEAT repeat {385-422}
HEAT repeat {426-463}
HEAT repeat {513-550}
HEAT repeat {554-596}
HEAT repeat {818-855}
HEAT repeat {872-910}
HEAT repeat {1102-1139}
HEAT repeat {1182-1219}
helicase
NAME: helicase
SITE: 1278-1453
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 1291-1298
Tyr phosphorylation site {Y1359}
DEGH box
SITE: 1404-1407
MOTIF-SEQUENCE: DEGH
Helicase C-terminal {1636-1790}
Database Correlations
OMIM 605191
UniProt O14981
PFAM correlations
Entrez Gene 9044
Kegg hsa:9044
References
UniProt :accession O14981