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TBC1 domain family member 1 (TBC1D1, KIAA1108)
Function:
1) GTPase activating protein for Rab family protein (putative)
2) role in the cell cycle & differentiation of various tissues (putative)
3) role in trafficking & translocation of GLUT4-containing vesicles & insulin-stimulated glucose uptake into cells
4) insulin-stimulated phosphorylation of TBC1D1 by AKT kinases stimulates SLC2A4/GLUT4 translocation
Structure:
- contains 1 PID domain
- contains 1 Rab-GAP TBC domain
Compartment: nucleus
Alternative splicing: named isoforms=2
General
nuclear protein
TBC1 domain family member
Properties
SIZE: entity length = 1168 aa
MW = 133 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S146}
Ser phosphorylation site {S235}
Ser phosphorylation site {S237}
phosphotyrosine interaction domain
NAME: phosphotyrosine interaction domain
SITE: 246-404
Ser phosphorylation site {S503}
Thr phosphorylation site {T505}
Ser phosphorylation site {S507}
Ser phosphorylation site {S525}
Ser phosphorylation site {S527}
Ser phosphorylation site {S565}
Ser phosphorylation site {S570}
Ser phosphorylation site {S571}
Ser phosphorylation site {S573}
Ser phosphorylation site {S585}
Thr phosphorylation site {T596}
Ser phosphorylation site {S614}
Ser phosphorylation site {S627}
rab-GAP domain
NAME: rab-GAP domain
SITE: 800-994
MOTIF: Ser phosphorylation site {S941}
Tyr phosphorylation site {Y952}
Thr phosphorylation site {T1131}
Database Correlations
OMIM 609850
UniProt Q86TI0
PFAM correlations
Entrez Gene 23216
Kegg hsa:23216
References
UniProt :accession Q86TI0